Publications

 

44. Madeline M. Keenen, David Brown, Lucy D. Brennan, Roman Renger, Harrison Khoo, Christopher R. Carlson, Bo Huang, Stephan W. Grill, Geeta J. Narlikar, Sy Redding (2020) HP1 proteins compact DNA into mechanically and positionally stable phase separated domains. Cold Spring Harb Laboratory, 2020; doi: https://doi.org/10.1101/2020.10.30.362772 {link}

43. Yi Zhang, Geeta J. Narlikar, Tatiana G. Kutateladze (2020) Enzymatic Reactions inside Biological Condensates. J. Mol. Biol; 

42. Sanulli S, Gross JD, Narlikar GJ (2020) Biophysical Properties of HP1-Mediated Heterochromatin. Cold Spring Harb Symp Quant Biol 2020 Jun 3;040360. doi: 10.1101/sqb.2019.84.040360. {link}

41. Dumesic PA, Stoddard CI, Catania S, Narlikar GJ, Madhani HD. (2020) ATP Hydrolysis by the SNF2 Domain of Dnmt5 Is Coupled to Both Specific Recognition and Modification of Hemimethylated DNA. Mol Cell. 2020 May 14;S1097-2765(20)30271-9.doi: 10.1016/j.molcel.2020.04.029. 

40. Srinivasan R, Nady N, Neha Arora N, Hsieh LJ, Swigut T, Narlikar GJ, Wossidlo M, Wysocka J (2020) Zscan4 Binds Nucleosomal Microsatellite DNA and Protects Mouse Two-Cell Embryos From DNA Damage. Sci Adv. 2020 Mar 20;6(12):eaaz9115.doi: 10.1126/sciadv.aaz9115. eCollection 2020 Mar. {link}

39. Narlikar GJ. (2020) Evolutionary Phase-separation in Chromatin Organization. J Biosci 2020;45:5. {link}

38. Catania S, Dumesic PA, Pimentel H, Nasif A, Stoddard CI, Burke JE, Diedrich JK, Cooke S, Shea T, Gienger E, Lintner R, Yates JR 3rd, Hajkova P, Narlikar GJ, Cuomo CA, Pritchard JK, Madhani HD. (2020) Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase. Cell. 2020 Feb 20;180(4):816. doi: 10.1016/j.cell.2020.02.006.{link}

37. Sanulli S, Trnka MJ, Dharmarajan V, Tibble RW, Pascal BD, Burlingame AL, Griffin PR, Gross JD, Narlikar, GJ (2019) HP1 reshapes the nucleosome core to promote phase separation of heterochromatin. Nature 575, 390–394 (2019) doi:10.1038/s41586-019-1669-2. {link}

36. Gebala M, Johnson SL, Narlikar GJ, Herschlag D. (2019) Ion counting demonstrates a high electrostatic field generated by the nucleosome. Elife. 2019 Jun 11;8. pii: e44993. doi: 10.7554/eLife.44993. {link}

35. Armache JP, Gamarra N, Johnson SL, Leonard JD, Wu S, Narlikar, GJ, Cheng Y. (2019) Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome. eLife June 18;8 pii: e46057. doi: 10.7554/eLife.46057.{link}

34. Stoddard CI, Feng S, Campbell MG, Liu W, Wang H, Zhong X, Bernatavichute Y, Cheng Y, Jacobsen SE, Narlikar, GJ. (2019) A nucleosome bridging mechanism for activation of a maintenance DNA methyltransferase. Mol Cell 2019 Jan 3;73(1):73-83.e6 {link}

33. Larson AG, Narlikar G.J. The role of phase separation in heterochromatin formation, function, and regulation. Biochemistry 2018, 57, 2540–2548.{link}

32. Gamarra N, Johnson SL, Trnka MJ, Burlingame AL, Narlikar GJ. (2018) The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h. eLife. Apr 17;7 pii: e35322. doi: 10.7554/eLife.35322. {link}

31. Zhou CY, Johnson SL, Lee LJ, Longhurst AD, Beckwith SL, Johnson MJ, Morrison AJ, Narlikar GJ. (2018) The Yeast INO80 Complex Operates as a Tunable DNA Length-Sensitive Switch to Regulate Nucleosome Sliding. Mol Cell {link}

30. Isaac RS, Sanulli S, Tibble R, Hornsby M, Ravalin M, Craik CS, Gross JD, Narlikar GJ. (2017) Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2. J Mol Biol {link}

29. Larson AG, Elnatan D, Keenen MM, Trnka MJ, Johnston JB, Burlingame AL, Agard DA, Redding S, Narlikar GJ. (2017) Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin. Nature {link}

28. Zhou CY, Stoddard CI, Johnston JB, Trnka MJ, Echeverria I, Palovcak E, Sali A, Burlingame AL, Cheng Y, Narlikar GJ. (2017) Regulation of Rvb1/Rvb2 by a Domain within the INO80 Chromatin Remodeling Complex Implicates the Yeast Rvbs as Protein Assembly Chaperones. Cell Reports 19(10):2033-2044 {link}

27. Sinha KK, Gross JD, Narlikar GJ. (2017) Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler. Science 355, 263.{link}

26. Isaac RS, Jiang F, Doudna JA, Lim WA, Narlikar GJ, Almeida R. (2016) Nucleosome breathing and remodeling constrain CRISPR-Cas9 function. eLife 2016;5:e13450. {link}

25. Leonard JD, and Narlikar GJ. (2015) A Nucleotide-Driven Switch Regulates Flanking DNA Length Sensing by a Dimeric Chromatin Remodeler Molecular Cell 57(5):850-9. {link}

24. Canzio D, Larson A, Narlikar GJ. (2014) Mechanisms of functional promiscuity by HP1 proteins. Trends Cell Bio. 24(6):377-386. {link}

23. Racki LR, Naber N, Pate E, Leonard J, Cooke R, Narlikar GJ. (2014) The histone H4 tail regulates the conformation of the ATP-binding pocket in the SNF2h chromatin remodeling enzyme. J. Mol. Bio. 426:2034-44. {link}

22. Narlikar GJ, Sundaramoorthy R, Owen-Hughes T. (2013) Mechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes. Cell 154(3):490-503. {link}

21. Al-Sady B, Madhani HD, Narlikar GJ. (2013) Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread. Mol Cell 51(1):80-91. {link}

20. Shiau C, Trnka MJ, Bozicevic A, Ortiz-Torres I, Al-Sady B, Burlingame AL, Narlikar GJ, Fujimori DG. (2013) Reconstitution of nucleosome demethylation and catalytic properties of a Jumonji histone demethylase. Chem Biol 20(4):494-9. {link}

19. Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ. (2013) A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature 496(7445):377-81. {link}

18. Rougemaille M, Braun S, Coyle S, Dumesic PA, Garcia JF, Isaac RS, Libri D, Narlikar GJ, Madhani HD. (2012) Ers1 links HP1 to RNAi. Proc. Natl. Acad. Sci. USA 109(28):11258-63. {link}

17. Shahian T, Narlikar GJ. (2012) Analysis of changes in nucleosome conformation using fluorescence resonance energy transfer. Methods Mol Biol 833:337-49. {link}

16. Armache KJ, Garlick JD, Canzio D, Narlikar GJ, Kingston RE. (2011) Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 Å resolution. Science 334(6058):977-82. {link}

15. Charles GM, Chen C, Shih SC, Collins SR, Beltrao P, Zhang X, Sharma T, Tan S, Burlingame, AL, Krogan NJ, Madhani HD, Narlikar, GJ. (2011) Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress. Proc. Natl. Acad. Sci. USA 108:10620-5. {link}

14. Canzio D, Chang EY, Shankar S, Kuchenbecker KM, Simon MD, Madhani HD, Narlikar GJ, Al-Sady B. (2011) Chromodomain-Mediated Oligomerization of HP1 Suggests a Nucleosome-Bridging Mechanism for Heterochromatin Assembly. Molecular Cell 41:67-81. {link}

13. Rowe CE, Narlikar GJ (2010) The ATP-Dependent Remodeler RSC Transfers Histone Dimers and Octamers through the Rapid Formation of an Unstable Encounter Intermediate. Biochemistry 49:9882-90. {link}

12. Racki LR, Yang JG, Nariman N, Partensky PD, Acevedo A, Purcell TJ, Cooke R, Cheng Y, Narlikar, GJ. (2009). The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes. Nature 462:1016-1021. {link}

11. Blosser TY, Yang JG, Stone MD, Narlikar GJ, Zhuang X. (2009). Dynamics of nucleosome remodelling by individual ACF complexes. Nature 462:1022-1027. {link}

10. Partensky PD, Narlikar GJ. (2009). Chromatin Remodelers Act Globally, Sequence Positions Nucleosomes Locally. J Mol Bio 391:12-25. {link}

9. Chang EY, Ferreira H, Somers J, Nusinow DA, Owen-Hughes T, Narlikar GJ. (2008). MacroH2A allows ATP-dependent chromatin remodeling by SWI/SNF and ACF complexes but specifically reduces recruitment of SWI/SNF. Biochemistry 47:13726–13732. {link}

8. Racki LR, Narlikar GJ. (2008). ATP-dependent chromatin remodeling enzymes: two heads are not better, just different. Curr Opin Genet Dev 18:137-144. {link}

7. Simon MD, Chu F, Racki LR, de la Cruz CC, Burlingame AL, Panning B, Narlikar GJ, Shokat KM. (2007). The site-specific installation of methyl-lysine analogs into recombinant histones. Cell 128:1003-1012. {link}

6. Yang JG, Narlikar GJ. (2007). FRET-based methods to study ATP-dependent changes in chromatin structure. Methods 41:291-295. {link}

5. Yang JG, Madrid TS, Sevastopoulos E, Narlikar GJ. (2006). The chromatin-remodeling enzyme ACF is an ATP-dependent DNA length sensor that regulates nucleosome spacing. Nature SMB 13:1078-1083. {link}

4. He X, Fan HY, Narlikar GJ, Kingston RE (2006).  Human ACF1 alters the remodeling strategy of SNF2h. J Biol Chem 281:28636-28647. {link}

3. Mahajan MC, Narlikar GJ, Boyapaty G, Kingston RE, Weissman SM. (2005). Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the {beta}-globin locus control region. Proc. Natl. Acad. Sci. USA 102:15012-15017. {link}

2. Fan H-Y, Narlikar GJ, Kingston RE. (2004). Noncovalent modification of chromatin: different remodeled products with different ATPase domains. Cold Spring Harb Symp Quant Biol 69:183-192. {link}

1. Fan H-Y, He X, Kingston RE, Narlikar GJ. (2003). Distinct Strategies to Make Nucleosomal DNA Accessible. Mol Cell 11:1311-1322. {link}